The regulatory properties of the neurospecific, type I adenylyl cyclase and its distribution within brain have suggested that this enzyme may be important for neuroplasticity. To address this issue, the murine, Ca2+ -stimulated adenylyl cyclase (type I), was inactivated by targeted mutagenesis. Ca2+ -stimulated adenylyl cyclase activity was reduced 40% to 60% in the hippocampus, neocortex, and cerebellum. Long term potentiation in the CA1 region of the hippocampus from mutants was perturbed relative to controls. Both the initial slope and maxim (...) um extent of changes in synaptic response were reduced. Although mutant mice learned to find a hidden platform normally in the Morris water task, they did not display a preference for the region where the platform had been when it was removed. The behavioral phenotype of these mice is very similar to that exhibited by mice which have been surgically lesioned in the hippocampus. These results indicate that disruption of the gene for the type I adenylyl cyclase produces changes in spatial memory and indicate that the cAMP signal transduction pathway may play an important role for synaptic plasticity. (shrink)

Evidence from invertebrate systems including Aplysia and Drosophila, as well as studies carried out with mammalian brain, suggests that Ca2+-sensitive adenylyl cyclases may be important for long-term synaptic changes and learning and memory. Furthermore, some forms of long-term potentiation (LTP) in the hippocampus elevate cyclic AMP (cAMP) signals, and activation of adenylyl cyclases and cAMP-dependent protein kinase may be required for late stages of LTP. We propose that long-term changes in neurons and at synapses may require synergism between the cAMP (...) and Ca2+ signal transduction systems which regulates transcription and synthesis of specific proteins required for long-term synaptic changes. During LTP, protein kinase C is activated and intraccllular Ca2+ increases. We hypothesize that the calmodulin (CaM)-regulated adenylyl cyclases may be activated during LTP because of increases in intracellular Ca2+, release of free CaM from neuromodulin, activation by protein kinase C, release of neurotransmitters, or a combination of these events. Synergistic activation of CaM-sensitive adenylyl cyclases may produce a robust or prolonged cAMP signal required for transcriptional control. Furthermore, the coupling of the Ca2+ and cAMP systems may provide positive feedback regulation of Ca2+ channels by cAMP-dependent protein kinase. (shrink)

Distinguished contributors take up eminent scholar Daniel R. Schwarz’s reading of modern fiction and poetry as mediating between human desire and human action. The essayists follow Schwarz’s advice, “always the text, always historicize,” thus making this book relevant to current debates about the relationships between literature, ethics, aesthetics, and historical contexts.

In short, he is known in a discipline in which he did not teach for a book he did not write. In Becoming Mead, Daniel R. Huebner traces the ways in which knowledge has been produced by and about the famed American philosopher.

This is the first modern book to describe Francis Bacon's jurisprudence. He has long been famous as a scientist, philosopher, politician and literary giant, but his career as one of England's greatest lawyers and jurists has been largely overlooked. Bacon's major contribution to Anglo-American jurisprudence is presented in such a way as to be suitable to specialists and non-specialists alike. The purpose is to restore Bacon to his rightful place as England's first true critical and analytical jurist, and to describe (...) how his legal thought related to his other great intellectual achievements. (shrink)

This dissertation is an investigation into the ground of moral objectivity. My preliminary claim is that in order to be objective, moral properties must be real properties. The following question is, what kind of properties are moral properties? A number of recent philosophers have argued that moral properties are natural properties. ''Natural" in this context means " open to investigation and discovery by the senses or by empirical science." The natural properties proposed in the recent literature are connected to the (...) property of human well-being. The main project of my dissertation is to show that natural properties are not adequate as the foundation for moral objectivity, because there is no necessary connection between any natural properties and moral properties. Another answer to the question of what kind of properties moral properties are is that they are supernatural properties. "Supernatural" in this context means "not open to investigation and discovery by the senses, or by empirical science." It is my argument that a singular supernatural being who created the world and has particular ideas about what sorts of people/actions/states of affairs are good and bad or right and wrong is the only sufficient ground for moral objectivity. Given such a being, moral properties will be real and objective. They will also be moral properties, since the originator of these properties confers value on them. Using and expanding on work in Divine Command Theory, especially that of Robert M. Adams, my original contribution to this discussion is to propose that moral properties are relational properties. The relationship is between persons, actions, states of affairs, etc., in the physical world, and the ideas, desires, character, or commands of the supernatural being. An important limitation of my dissertation project is that I do not consider any practical issues such as "How do we know whether God exists?", "How would God communicate the content of morality to us?", or "What is God like?" These are important and worthwhile questions, but are not a part of my present investigation. (shrink)

This dissertation explores issues in the philosophy of psychology and metaphysics through the lens of the emotion of disgust, and its corresponding property, disgustingness. The first chapter organizes an extremely large body of data about disgust, imposes two constraints any theory must meet, and offers a cognitive model of the mechanisms underlying the emotion. The second chapter explores the evolution of disgust, and argues for the Entanglement thesis: this uniquely human emotion was formed when two formerly distinct mechanisms, one dedicated (...) to monitoring food intake and protecting against poisons, the other dedicated to protecting against parasitic infection, where driven together until they became functionally integrated. The third chapter explores the sorts of acquisition mechanisms that could give rise to the patterns of individual and cultural level variation we find with disgust elicitors. It argues for the Empathic Acquisition thesis, which holds that one important route for the social acquisition and transmission of disgust elicitors is linked to empathic recognition of facial expressions of the emotion. The fourth chapter builds on the Entanglement thesis, and embeds the emotion of disgust in gene-culture coevolutionary theory and the tribal instincts hypothesis. The Co-opt thesis is defended, which maintains that disgust was co-opted to play an important role in our moral psychology, particularly in our cognition of social norms and ethnic boundary markers. In doing so, however, it brings to bear many features initially linked to poisons and parasites. This explains the puzzling and troublesome character of moral judgments linked to disgust. After shifting gears from psychology to metaphysics, the fifth chapter recasts the Humean tradition of projectivism in the terminology of cognitive science. Using examples such as disgust, I argue that a psychologized projectivism is able to make sense of the idea that some properties are projected onto the world, rather than found there to begin with. The final chapter criticizes three other accounts of the property of disgustingness, two inspired by functionalism in the philosophy of color, one inspired by fittingness accounts in metaethics. I argue that none provide nearly as satisfactory account of the property as the psychologized projectivism articulated previously. (shrink)

Plagiarism is increasingly evident in business and academia. Though links between demographic, personality, and situational factors have been found, previous research has not used actual plagiarism behavior as a criterion variable. Previous research on academic dishonesty has consistently used self-report measures to establish prevalence of dishonest behavior. In this study we use actual plagiarism behavior to establish its prevalence, as well as relationships between integrity-related personal selection and workplace deviance measures. This research covers new ground in two respects: (a) That (...) the academic dishonesty literature is subject to revision using criterion variables to avoid self bias and social desirability issues and (b) we establish the relationship between actual academic dishonesty and potential workplace deviance/white-collar crime. (shrink)

The fundamental postulate of sociobiology is that individuals exploit favorable environments to increase their genetic representation in the next generation. The data on fertility differentials among contemporary humans are not cotvietent with this postulate. Given the importance ofHomo sapiensas an animal species in the natural world today, these data constitute particularly challenging and interesting problem for both human sociobiology and sociobiology as a whole.The first part of this paper reviews the evidence showing an inverse relationship between reproductive fitness and “endowment” (...) (i.e. wealth, success, and measured aptitudes) in contemporary, urbanized societies. It is shown that a positive relationship is observed only for those cohorts who bore their children during a unique period of rising fertility, 1935–1960, and that these cohorts are most often cited by sociobiologists as supporting the central postulate of sociobiology. Cohorts preceding and following these show the characteristic inverse relationship between endowment and fertility. The second section reviews the existing so-ciobiological models of this inverse relationship, namely, those of Barkow, Burley, and Irons, as well as more informal responses among sociobiologists to the persistent violation of sociobiology's central postulate, such as those of Alexander and Dawkins. The third section asks whether the goals of sociobiology, given the violation of its fundamental postulate by contemporary human societies, might not be better thought of as applied rather than descriptive, with respect to these societies. A proper answer to this question begins with the measurement of the pace and direction of natural selection within modern human populations, as compared to other sources of change. The vast preponderance of the shifts in human trait distributions, including the IQ distribution, appears to be due to environmental rather than genetic change. However, there remains the question of just how elastic these distributions are in the absence of reinforcing genetic change. (shrink)

This book tries to look at human thought and action from a scientific perspective, and in the process, acquaints the reader with essential concepts about science and its history. It takes a broad look at our present troubles without overlooking some crucial historical, religious, and political causes but places science at the center stage. The author applies what he has learned throughout his career to go beyond science. After an introduction setting the scene and a review of the "scientific temper" (...) and the inexcusable ignorance of science by some leaders and many followers, the author turns his sharp vision to look at other issues. The most significant challenges are critical and global: climate change caused by our activities, stockpiles of nuclear weapons that are a constant threat, population growth, and increasing inequality at all levels. These problems do have a profound ethical character and threaten to end forever with our misery, producing a "catastrophic convergence". Written with rigor for all readers, with many references and infused with relevant quotations, the author's message is clear: we need to change our ways drastically and urgently, now or never. But he offers not much in terms of a solution, something done by many authors to sweeten the pill, because as he argues, beyond lofty declarations, there is no real solution as the clock runs down, leading to his dystopian view of the future. (shrink)

This dissertation argues for a metaethical theory I call "Expressive-Assertivism." Expressive-Assertivism is a distinctive, substantial refinement of dual-use metaethical theories traditionally associated with R. M. Hare, C. L. Stevenson, and, more recently, with David Copp. If true, Expressive-Assertivism clarifies, resolves, or dissolves---without, in turn, raising additional difficulties---a number of philosophical problems, including what Michael Smith calls "The Moral Problem," which many consider to be the central organizing problem in contemporary metaethics. The following are the three most important features of Expressive-Assertivism. (...) ;1. The central tenet. The proper, literal use of an ethical sentence, such as 'Donating to charity is right', is the performance of a direct expressive illocutionary act and a direct assertive illocutionary act. Recognizing that ethical sentences can be used to both directly express a speaker's attitude and directly assert something about the world captures what is intuitively compelling about "expressivist" theories---namely, that there is some strong connection between a speaker's sincere moral utterance and his or her motivations to act---and what is intuitively compelling about "descriptivist" theories---namely, that moral utterances appear to have descriptive or cognitive content and, therefore, are truth-evaluable. The Central Tenet is the feature of Expressive-Assertivism that dissolves The Moral Problem. ;2. The generality principle. The proper, literal use of an ethical sentence directly expresses an attitude, not toward the subject of the sentence, but toward things of a more general kind, namely, things that have the property picked out by the ethical predicate . ;3. The extensionality principle. A speaker directly expresses an attitude toward things that have the property picked out by an ethical predicate whenever that predicate appears in any extensional context. Together, the Extensionality and Generality Principles shield Expressive-Assertivism from many objections to traditional expressivist theories, including "The Embedding Objection," which many consider to be the most difficult problem faced by expressivists. (shrink)

This book comprises essays that focus on a range of thinkers that challenge the boundaries of the just war tradition. The ethics of war scholarship has become a rigid and highly disciplined activity, closely associated with a very particular canon of thinkers. This volume moves beyond this by presenting thinkers not typically regarded as part of that canon, but who have interesting and potentially important things to say about the ethics of war. The book presents twenty profile essays on an (...) eclectic cast of heretics, humanists, and radicals, from Epictetus to Rosa Luxemburg to Frantz Fanon and Judith Butler. The book asks whether there is a good reason for the marginalisation of these thinkers and what ethics of war scholars might benefit from engaging with them. Some of these thinkers engage directly with-to augment or criticise-the just war tradition, while others contribute to military thinking across the ages and push the boundaries of what was acceptable in war. Many proffer alternative moral frameworks regarding the legitimacy of political violence. The present volume thus invites scholars to reconsider the ethics of war in a way that challenges the standard delineation between just war theory, realism, and pacifism, and to reflect on how those positions might inform our own approach to these matters. This book will be of much interest to students of just war theory, ethics of war, war studies and International Relations. (shrink)

pt. 1. Toward a theory of liberal education. Mixed messages and false starts -- Liberal education and human flourishing -- pt. 2. Paradigms of liberal education. Transmission of culture -- Self-actualization -- Understanding the world -- Engagement with the world -- The skills of learning -- pt. 3. The values and moral aims of liberal education. Core values of liberal education -- Intrinsic value -- Educating a good person -- pt. 4. Obstacles, threats and prospects. Persistent concerns -- Newfound threats (...) -- Promise and prospects. (shrink)